5/25/11

Poor Eating Habits May Lead to Anemia in Older Women

Study finds that as nutrient intake declines, risk rises
FRIDAY, March 25 (HealthDay News) -- A poor diet is associated with a greater risk of developing anemia among postmenopausal women, a new study has found.
Researchers analyzed data from 72,833 older women in the United States and found that deficiencies in more than a single nutrient were associated with a 21 percent increased risk of persistent anemia. Risk increased 44 percent with deficiencies in three nutrients.
Women with anemia consumed less protein, folate, vitamin B12, iron, vitamin C and red meat than did others, the study found. The results are published in the April issue of the Journal of the American Dietetic Association.
Inadequate nutrient intake was less frequent among whites than in other racial or ethnic groups: 7.4 percent, compared with 14.6 percent of Asian/Pacific Islanders, 15.2 percent of Native Americans/Alaskans, 15.3 percent of blacks and 16.3 percent of Hispanics.
The researchers also found that the use of multivitamin and mineral supplements was not associated with lower rates of anemia. Age, body mass index and smoking were associated with anemia.
Anemia has been linked to an increased risk of death and, "anemia, particularly iron deficiency, has been associated with reduced capacity for physical work and physical inactivity, injury related to falls and hospitalizations, making this an important health-care concern in the aging," lead investigator Cynthia A. Thomson, associate professor of nutritional sciences at the University of Arizona in Tucson, said in a journal news release.
"Efforts to identify anemia that may be responsive to modifiable factors, such as diet to improve health outcomes, are needed," the researchers concluded. "Additional efforts to regularly evaluate postmenopausal women for anemia should be considered and should be accompanied by an assessment of dietary intake to determine adequacy of intake of anemia-associated nutrients, including iron, vitamin B12 and folate," they wrote.
"While the type of anemia is often designated by a more comprehensive biochemical assessment than hemoglobin alone, nutritional therapy to improve overall nutrient-density and quality of the diet should also be a clinical focus," Thomson and colleagues said.

5/24/11

4-year-old cured of Thalassemia major with stem cell transplant

Ahmedabad doctorshave carried out a rare successful stem cell transplant on a four-year-old girl suffering from Thalassemia major, relieving her of life-long blood transfusions.
Isha Gohel from Saurastra, who was diagnosed of suffering from advanced stages of Thalassemia, had started receiving blood transfusions at the age of 18 months.
When she was brought to Apollo hospital in Ahmedabad, doctors after investigations found that she was a case of class 3 Thalassemia Major. Since she did not get good quality blood transfusion, her condition was very poor. She had developed marked enlargement of the spleen leading to further poor response to blood transfusions.
Terming Isha's case as challenging, Dr Chirag A Shah, haematologist, Apollo hospital here, said that they followed the style of treatment of Dr G Lucarelli from the Mediterranean Institute of Haematology - an international centre for transplantation in thalassemia and Sickle Cell Anaemia - in Italy who has successfully treated advanced cases of thalassemia.
Her spleen was removed and stems cells from Isha's two-year-old brother were transplanted. "We followed his (Lucarelli's) formulae for treatment of Isha and we were successful," he said.
"Stemcell transplant in advanced cases of thalassemia results in poor outcome. Such patients are not advised a transplant as they frequently have poor results and have high risk of complications," Shah said.
He said that Isha's case was difficult for them as her spleen had blown out of proportion and her liver too was damaged due to iron deposits.
Giving details of her treatment, he said, "We first surgically removed her spleen in January and the following month we started on a special protocol of medicines to reduce her risk of being Class 3. This continued for over one month until finally she underwent stem cell transplant procedure in April. The stem cells were from her younger brother."
Isha is now on the road to recovery and and will be transfusion free forever as her underlying Thalassemia major is now cured after stem cell transplant.